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On-Demand Webinar: icIEF Charge Variant Fractionation and ZipChip-MS based Characterization

Hosted by ProteinSimple, a Bio-Techne brand, and 908 Devices


A thorough characterization of a biopharmaceutical drug candidate is critical during development to attain the ultimate goals of commercializing a safe and efficacious therapeutic for patients. An important regulatory requirement is to characterize charge variants. The traditional technique used by Maurice icIEF users is to develop an ion exchange chromatography assay, collect fractions on a semi-prep column and analyze them using a mass spectrometer. ProteinSimple has developed a fractionation capable icIEF solution and is collaborating with 908 Devices in charge variant characterization using their ZipChip device connected to a mass spec, providing a complete workflow for charge variant analysis.

The presentation will include the analysis of a monoclonal antibody along with the NIST mAb and will present icIEF fractionation and characterization data. In addition, there will be a brief overview of the capabilities of the ZipChip.

Attendees will learn about:

  • The new charge variant characterization solution
  • How this solution will offer workflow enhancements
  • The capabilities of the ZipChip
Speakers

Nagalakshmi Sooriyanarayanan, Ph.D.

Nagalakshmi Sooriyanarayanan, Ph.D.
Research Scientist, R&D Science
ProteinSimple, a Bio-Techne Brand


Nagalakshmi Sooriyanarayanan, a Scientist in the R&D Science group at ProteinSimple, a Bio-Techne brand, received her MS-PhD degree in Biophysics from Universidad Autónoma de Madrid, Spain. For her PhD research, she joined Spanish National Research Council (CIB-CSIC, CNB-CSIC), where she focused on understanding complex protein folding mechanisms, and gained expertise in custom-built instrumentation focused on protein biophysical characterization. She received the Marie Curie award from the European Union and ‘Formación de Profesorado Universitario’ Predoctoral Fellowship for her doctorate work. After graduate school, she joined Aragen Life Sciences, where she routinely used various protein analytical tools for preclinical projects. This path naturally led her to her current role at ProteinSimple, where she works on development of novel electrophoretic platforms. Nagalakshmi is an expert in protein biophysics and analytics.
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Scott Mellors, Ph.D.
Principal Scientist
908 Devices

Scott Mellors, Principal Scientist at 908 Devices, received his Ph.D. from UNC-Chapel Hill in 2005, having worked on Ultra High Pressure Liquid Chromatography under the direction of James Jorgenson. He then began working in Mike Ramsey’s lab on the problem of how to efficiently couple microfluidic separations with mass spectrometry. After nearly 10 years, Scott joined the team at 908 Devices where he has led the scientific development of 908 Device’s microchip CE-MS technology. This has led to the launch of two products: ZipChip and Rebel. While these devices already outperform alternative methods in many ways, Scott and the rest of the team at 908 Devices have only begun to take advantage of the speed, sensitivity, and flexibility enabled by microfluidic integration. Today they are working to broaden and fully optimize the applications on both platforms, while also working to push the technology further. Scott is an expert in the fields of separations, microfluidics, and mass spectrometry.


Webinar: icIEF Charge Variant Fractionation and ZipChip