Webinar

Evaluation and application of Maurice for biopharmaceutical analysis
December 6, 2017

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Charge and size profiling are critical steps in protein characterizing for the development of biopharmaceutics and vaccines. Regulatory agencies require that critical quality attributes are monitored and imaged capillary isoelectric focusing (icIEF) and capillary electrophoresis sodium dodecyl sulfate (CE-SDS) technologies are the industry standard for analyzing protein purity, identity, and heterogeneity. Maurice combines both icIEF and CE-SDS detection schemes in one system, which automates protein profiling by either size or charge.

In this webinar, our panelists will discuss the application of Maurice for biopharmaceutical analysis. The panelists will discuss an evaluation of Maurice for biopharmaceutical charge and size profiling; a comparability study of Maurice, iCE3 and a conventional CE system; applications to fluorescence detection and aglycosylated mAB quantitation; and the characterization of lipid nanoparticles, a heterogeneous mixture of large polydisperse particles.

Speakers:

Xiaoping He
Senior Scientist
Pfizer, Inc.

John Loughney
Associate Principal Scientist
Merck & Co., Inc.

Title of the presentation:

• How is Maurice doing: Charge and Size Profiling for Biotherapeutic Modalities
• Characterization of CRM197 for conjugate vaccine using icIEF (Maurice) and Capillary Western (SimpleWestern)