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Natural Killer Cells or Contaminant? Imaged Based Micro-Flow Imaging (MFI), Sub-Visible Particle Solution, for Cell Therapy

Recorded: June 29, 2021
Available: On-Demand

Natural killer (NK) cell therapy is a rapidly emerging field with several advantages over chimeric antigen receptor (CAR) T-cells for cancer treatment. Like any biotherapeutic drug, cell-based therapeutics must also undergo tight scrutiny for their critical quality attributes (CQAs). There are different criteria evaluated for drug purity, with the presence of visible and sub-visible particulate matter being one of them. Particulate impurities can affect drug efficacy and stability but can cause undesirable immunogenicity and toxicity when injected. In this webinar, we will showcase Micro-Flow Imaging (MFI) as a sub-visible particle analysis solution to differentiate NK cells and its expansion components with either irradiated K-562 feeder cells or Cloudz™ microspheres.

Attendees will learn about:
• Considerations regarding the methodology of NK cells expansion
• Identifying sources of particle contamination from ancillary materials
• Showcasing MFI analysis of NK cells from irradiated K-562 feeder cells or Cloudz™ microspheres



Daryl Taketa, Ph.D.
Applications Scientist, Field Applications
ProteinSimple, a Bio-Techne Brand

Daryl Taketa is an Applications Scientist at ProteinSimple, a Bio-Techne Brand, that provides solutions from R&D to downstream analysis workflows through their instrumentation portfolio. Daryl received a BS in Biology at Santa Clara University and his PhD in Molecular, Cellular and Developmental Biology at University of California – Santa Barbara, where he studied allorecognition (self- versus non-self-recognition) in a basal chordate.

MFI Instrument