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PAS Webinar: Use of RNAscope™ ISH Services for T Cell Therapy Detection & Quantification

Tuesday, December 15, 2020 @ 10am PST | 1pm EST | 7pm CEST

RNAscope in situ hybridization (ISH) is the only method for specific detection of engineered CAR-T and TCR-T cell therapies in clinical trial patient biopsies. IHC is unable to differentiate engineered T cells from endogenous cells. However, RNAscope probes targeting viral untranslated regions (UTRs) common to CAR and TCR mRNAs, enable specific detection and quantification of CAR/TCR-T cells in the tumor microenvironment (TME).

RNAscope UTR probes are easily multiplexed with probes to assess activation, e.g., IFNG and GZMB, as well as with T cell IHC markers, e.g. CD3, CD4, CD8 to measure T cell recruitment. These assays are used to monitor T-cell therapies in post-treatment patient biopsies and in preclinical animal models of safety and efficacy.


Key advantages of RNAscope cell therapy assays:

  • Simultaneously detect CAR/TCR-T cells with cytokines, immune cell markers and target antigens
  • Quantification of cell therapy tumor and stromal distribution and T cell recruitment

  • Patient biopsy analysis to link cell therapy pharmacokinetics/pharmacodynamics and efficacy


SPEAKER

Chris Bunker.png

Christopher Bunker, Ph.D.
Sr. Director, Business Development
Advanced Cell Diagnostics, a Bio-Techne Brand

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